Preliminary human safety assessment (PHSA) for the improvement of the behavioral aspects of safety climate in the construction industry

Occupational safety in the construction industry still represents a relevant problem at a global level. In fact, the complexity of working activities in this sector requires a comprehensive approach that goes beyond normative compliance to guarantee safer working conditions. In particular, empirical research on the factors influencing the unsafe behavior of workers needs to be augmented. Thus, the relationship between human factors and safety management issues following a bottom-up approach was investigated. In particular, an easy-to-use procedure that can be used to better address workers' safety needs augmenting the company's safety climate and supporting safety management issues was developed. Such an approach, based on the assessment of human reliability factors, was verified in a real case study concerning the users of concrete mixer trucks. The results showed that the majority of human failures were action and retrieval errors, underlining the importance of theoretical and practical training programs as a means to improve safety behavior. In such a context, information and communication activities also resulted beneficially to augment the company's safety climate. The proposed approach, despite its qualitative nature, allows a clearer understanding of workers' perceptions of hazards and their risk-taking behavior, providing practical cues to monitor and improve the behavioral aspects of safety climate. Hence, these first results can contribute to augmenting safety knowledge in the construction industry, providing a basis for further investigations on the causalities related to human performances, which are considered a key element in the prevention of accidents

Building information modelling (BIM) to enhance occupational safety in construction activities. Research trends emerging from one decade of studies

In recent years, the use of new technologies is rapidly transforming the way working activities are managed and carried out. In the construction industry, in particular, the use of Building Information Modelling (BIM) is ever increasing as a means to improve the performances of numerous activities. In such a context, several studies have proposed BIM as a key process to augment occupational safety effectively, considering that the construction industry still remains one of the most hazardous working sectors. The purpose of the present study is to investigate the recent research addressing the use of BIM to improve construction safety. A systematic review was performed considering journal papers that appeared in literature in the last decade. The results showed that the most viable and promising research directions concern knowledge-based solutions, design for safety improvement through BIM solutions, transversal applications of BIM, and dynamic visualization and feedback. The findings of this study also indicated that more practical BIM applications are needed, especially focusing on safety training and education, the use of BIM to augment safety climate and resilience, and the development of quantitative risk analysis to better support safety management. Overall, the study provided a comprehensive research synthesis augmenting knowledge on the role of BIM-based tools in construction safety, which can be considered a reference framework to enhance workers' safety by means of these new technologies

A BIM-based PSS approach for the management of maintenance operations of building equipment

The service-centered economy has grown considerably in the last few years, shifting from product-based solutions towards service centered offerings, i.e., Product-Service System (PSS) solutions. Such an approach is also emerging in the context of building equipment, where maintenance activities play a fundamental role in facility management. In this field, Building Information Modeling (BIM) based tools are diffusely used to improve the performances of facility management. However, few studies have addressed the above issues while considering a shift from product-based approaches in favor of more advanced servitization models. The study aims at integrating BIM based approaches in a PSS context for the improvement of the management of maintenance operations of building equipment. A general framework for maintenance management has been developed, merging the implementation of the PSS components in a BIM model for the definition of maintenance management. A first application of this methodology to a real case study concerning the elevators of an existing building has shown the efficacy of the proposed approach. The study highlighted the benefits that can be achieved, especially in terms of reduced periods of equipment unavailability, reduced costs and augmented customer satisfaction, while enhancing the information exchange between the PSS actors. Hence, although further research is still needed for its validation, the proposed approach can offer practical insights for the development of promising BIM-based PSS solutions for facility management in the construction industry

Safety vision of agricultural tractors. An engineering perspective based on recent studies (2009-2019)

The high rate of injuries occurring in agricultural activities is of major concern in most countries, despite the ever-increasing efforts made at normative levels. In particular, the use of agricultural tractors is recognized as the most hazardous activity for farmers due to the large number of fatalities occurring every year. The aim of the present study was to investigate the recent developments in research activities dealing with tractor safety. For this purpose, a systematic literature review was carried out, taking into account engineering journal papers appearing in Scopus in the 2009-2019 period and focusing on tractor safety. As a result, 79 documents were selected and analyzed based on both their type (e.g., conceptual or empirical studies) and specific targets. They were then classified and discussed in accordance with a reference framework representing the main issues of agricultural tractor safety: mechanical hazards, protective devices, command and control, other hazards, ergonomics, information, conformity, and user behavior. The results of this analysis brought to light the need for a more human-centered approach when dealing with tractor safety. In addition, the lack of a reliable framework of technical standards was also stressed. Overall, despite the limitations due to the selection criteria, this study represents the first systematic literature review depicting the status of tractor safety in the engineering field, providing a basis for further research on the emerging themes outlined

NOSACQ-50 for safety climate assessment in agricultural activities. A case study in central Italy

Safety climate assessment has been recognized as a powerful tool to bring to light workers’ perceptions related to safety practices, attitudes and behaviors at the workplace. Accordingly, its investigation can provide useful information about safety problems within a company before accidents occur. In literature, numerous studies can be found investigating safety climates in different types of industry. However, safety climate assessment in agricultural activities is addressed scarcely, even though agriculture represents a very hazardous sector. To reduce this gap, the present study proposes an investigation of safety climate among farmers by means of the Nordic Safety Climate Questionnaire (NOSACQ-50). The results of the survey brought to light a low level of safety perception of the interviewed sample, especially as concerns safety commitment and risk-taking attitudes. In particular, a different attitude toward safety issues has been registered depending on both the position and gender of the interviewed farmers. Overall, the output of this cross-sectional analysis adds to the current literature by expanding knowledge of safety climate among farmers, representing a baseline for further investigations based on human-centered approaches to enhance safety in agriculture and consequently social and workplace aspects of sustainable agricultural systems

Ultraviolet and Infrared Divergences in Implicit Regularization: a Consistent Approach

Implicit Regularization is a 4-dimensional regularization initially conceived to treat ultraviolet divergences. It has been successfully tested in several instances in the literature, more specifically in those where Dimensional Regularization does not apply. In the present contribution we extend the method to handle infrared divergences as well. We show that the essential steps which rendered Implicit Regularization adequate in the case of ultraviolet divergences have their counterpart for infrared ones. Moreover we show that a new scale appears, typically an infrared scale which is completely independent of the ultraviolet one. Examples are given.Comment: 9 pages, version to appear in Mod. Phys. Lett.

Successful transduction with AAV vectors after selective depletion of anti-AAV antibodies by immunoadsorption

Gene therapy with adeno-associated virus (AAV)-based vectors shows great promise for the gene therapeutic treatment of a broad array of diseases. In fact, the treatment of genetic diseases with AAV vectors is currently the only in vivo gene therapy approach that is approved by the US Food and Drug Administration (FDA). Unfortunately, pre-existing antibodies against AAV severely limit the patient population that can potentially benefit from AAV gene therapy, especially if the vector is delivered by intravenous injection. Here, we demonstrate that we can selectively deplete antiAAV antibodies by hemapheresis combined with AAV9 particles coupled to Sepharose beads. In rats that underwent hemapheresis and immunoadsorption, luciferase expression was dramatically increased in the hearts and fully restored in the livers of these rats. Importantly, our method can be readily adapted for the use in clinical AAV gene therapy.Fil: Orlowski, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina. Icahn School of Medicine at Mount Sinai. Graduate School of Biomedical Sciences. Cardiovascular Institute; Estados UnidosFil: Katz, Michael G.. Icahn School of Medicine at Mount Sinai. Graduate School of Biomedical Sciences. Cardiovascular Institute; Estados UnidosFil: Gubara, Sarah M.. Icahn School of Medicine at Mount Sinai. Graduate School of Biomedical Sciences. Cardiovascular Institute; Estados UnidosFil: Fargnoli, Anthony S.. Icahn School of Medicine at Mount Sinai. Graduate School of Biomedical Sciences. Cardiovascular Institute; Estados UnidosFil: Fish, Kenneth M.. Icahn School of Medicine at Mount Sinai. Graduate School of Biomedical Sciences. Cardiovascular Institute; Estados UnidosFil: Weber, Thomas. Icahn School of Medicine at Mount Sinai. Graduate School of Biomedical Sciences. Cardiovascular Institute; Estados Unido

Regularization Independent Analysis of the Origin of Two Loop Contributions to N=1 Super Yang-Mills Beta Function

We present a both ultraviolet and infrared regularization independent analysis in a symmetry preserving framework for the N=1 Super Yang-Mills beta function to two loop order. We show explicitly that off-shell infrared divergences as well as the overall two loop ultraviolet divergence cancel out whilst the beta function receives contributions of infrared modes.Comment: 7 pages, 2 figures, typos correcte

Centrifuge modelling of the behaviour of pile groups under vertical eccentric load

Annular shaped pile groups are a very common foundation layout for onshore wind turbines and other slender structures. In this study, their performance under vertical loads of moderate to high eccentricity, including moment rotation response and bearing capacity, was investigated by centrifuge testing on small scale physical models embedded in kaolin clay. To identify experimentally the capacity of the examined pile groups under different load paths, the model foundations were loaded monotonically until a clear collapse mechanism was achieved. The testing procedure and the proposed interpretation methodology can be easily adapted to load paths or pile layouts other than those considered in the current study. The experimental data can be adopted as a useful benchmark for mathematical models aimed at predicting the response of pile groups to complex load paths. The results of this testing program can also be used to assess the degree of conservatism of current methods adopted by industry for the design of piled foundations subjected to eccentric loads

Disease Severity Is Associated with Alexithymia in Patients with Atopic Dermatitis

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder that is associated with higher rates of psychological disorders, but limited evidence supported the association with alexithymia, a psychoaffective dysfunction. Objectives: This study was aimed to investigate the occurrence of alexithymia in AD patients, compared to healthy subjects. Methods: This cross-sectional study assessed AD severity by the Eczema Area and Severity Index (EASI) score, sleeplessness and itch by a numeric rating scale (NRS), and alexithymia by the 20-item Toronto Alexithymia Scale (TAS-20) score. The association between disease characteristics and alexithymia was evaluated through several logistic regression models. Results: 202 AD patients and 240 healthy subjects were included in this study. The alexithymic personality trait (TAS-20 >= 51) was more frequently observed among AD patients compared to the control group (62.4% [126/202] vs. 29.2% [70/240], p < 0.0001). In particular, alexithymia (TAS-20 score >= 61) was detected in a significantly higher number of AD patients than in the controls (27.7% [56/202] vs. 7.5% [18/240]; p < 0.0001), whereas borderline alexithymia was detected in 34.6% (70/202) of AD patients compared to 21.7% of healthy controls. Alexithymia was more common among severe AD patients (43.6%) compared to mild AD patients (15.6%) and correlated with itch intensity and sleep disturbances. Among clinical variables, ordered logistic regression analyses revealed disease severity as predictor of alexithymia. Indeed, univariate analysis showed EASI score, sleep NRS, and itch NRS being significantly associated with alexithymia, while a multivariate model identified increased EASI score values as predicting factor. Conclusion: This study described alexithymia in AD patients correlating its occurrence with clinical AD severity markers (EASI score, itch, and sleeplessness) and identifying the increase in EASI score as predicting factor. (c) 2020 S. Karger AG, Base